Coming from California and already being west of the Continental Divide, we filed our international flight plan from Oroville, WA to Kamloops, BC. From Kamloops, our route to AK was Williams Lake, BC - Smithers, BC- Dease Lake,BC - Whitehorse,YT - Dawson City, YT - Eagle,AK. I wouldn't recommend that route if solo; I was one in a group of three airplanes. There are places between Dease Lake and Teslin that are 100 miles from ANYTHING man-made, and without floats there are very few options for a successful off-field landing. With a group, at least someone knows where to tell the rescuers to go. If I were ever to do it single-ship, I'd probably stick to the Highway all the way.
In Whitehorse, the on-airport accomodations were full, but there was a decent motel within walking distance across the highway. We were weathered in in Whitehorse a full day, so we rented a car for the 2.5-hour drive down to Skagway. Well worth the trip, (but don't forget your passport). On the return fight, we stayed in town where the accomodations were only about half the price of the motel near the airport, but we did have to get a ride in. There's a lot of history in Whitehorse; I especially enjoyed the SS Klondike sternwheel riverboat.
From Whitehorse we flew the length of Lake Leberge, then to Dawson, YT, focal point of the Klondike gold rush. We spent a half day there taking in the Gold Rush history and readings of Robert Service, poet laurate of the Yukon. The easiest navigation of the trip was from Dawson to Eagle. From the Dawson airport a few miles east of town you follow the Klondike River to town where it joins the Yukon River, follow that to the Alaska border, which is an unmistakable clear-cut through the trees on the 141st meridian, then around right, then left bends in the river where you'll see the airport on a hill south of the river. Eagle is an interesting little town with a population just barely into 3 digits, overlooking the Yukon River. Its airport is a gravel runway, yet is a customs landing rights airport. The customs office was an aged Chevy Suburban manned by a single agent who lived in the local B&B.
From Eagle, we landed in Tok Junction, Manley Hot Springs, Denali National Park, and Talkeetna before arriving at Merrill field in Anchorage. We camped in Eagle and Denali. The only place mosquitos (the Alaska State Bird

Manley Hot Springs was also an interesing visit, located in the central part of the state, and just about the furthest into the interior you can get by road. We found the hot springs within walking distance of the airport, but the OAT was well into the 80's, with a humidity to match, sot the springs weren't very appealing at the time. I have read where this is a popular ski-plane destination in the winter. We did have a nice visit with the hot springs caretaker who was an amateur photographer with some interesting photos of up close and personal encounters with polar bears durinig his travels. We had to buy fuel out of someone's personal stock so we'd have enough to make Denali, then Talkeetna to refuel. The price was $50 for 15 gallons, about a $1/gallon more than the average for the rest of the trip.
On the return trip from Anchorage, the group I flew up with wanted to fly down the coast route, but I opted to follow the highway with a different group. Normally you can't expect a lot of VFR weather along the coast, but as it turned out the ones that went that way were home in 2 days, where it took us a week of fighting the weather inland. go figure.

At that time, Canadian customs was a no-brainer. I never met a Canadian customs agent; it was taken care of by phone (1-800-CANPASS) both times. I'm not sure that is how it works anymore.
Miles